School of Psychology, Northeast Normal University, No. 5268 Renmin Street, Changchun 130024, China.
School of Psychology, Northeast Normal University, No. 5268 Renmin Street, Changchun 130024, China; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, Changchun,Jilin 130024, China.
Psychiatry Res Neuroimaging. 2023 Oct;335:111722. doi: 10.1016/j.pscychresns.2023.111722. Epub 2023 Oct 4.
HIV infection is known to have significant effects on central nervous system. This study conducted a meta-analysis of whole voxel-based morphometry (VBM) in HIV patients (N = 435) and HIV-uninfected controls (N = 397). This study observed a reduction of limbic lobe, cingulate gyrus, frontal lobe, middle frontal gyrus, sub-lobar, insula, inferior frontal gyrus and superior frontal gyrus volume in HIV patients. These morphological differences may be responsible for cognitive decline in HIV patients, as these brain regions are closely related to motor and memory functions. These results contribute to a better understanding of the neural mechanisms underlying brain injury in HIV patients and could help develop targeted brain targets, provide more personalized treatment and predict neurodevelopmental outcomes.
已知 HIV 感染对中枢神经系统有重大影响。本研究对 435 名 HIV 患者和 397 名未感染 HIV 的对照组进行了全脑基于体素的形态计量学（VBM）荟萃分析。本研究观察到 HIV 患者的边缘叶、扣带回、额叶、额中回、旁小叶、岛叶、额下回和额上回体积减少。这些形态学差异可能是导致 HIV 患者认知能力下降的原因，因为这些脑区与运动和记忆功能密切相关。这些结果有助于更好地理解 HIV 患者脑损伤的神经机制，并可能有助于开发针对大脑的目标，提供更个性化的治疗方案并预测神经发育结果。
