Bezverkhaia T P, Varga S V, Verkhogliadova L M
Probl Endokrinol (Mosk). 1986 Sep-Oct;32(5):48-51.
The concentration of testosterone and estradiol in the blood plasma and the binding capacity of testosterone-estradiol binding globulin (TEBG) were studied in 30 women and 6 men with Icenko-Cushing's disease in the active phase and in 24 women with hormonally active adrenal tumors. In hypercorticism against a background of unchanged of lowered concentration of plasma estradiol there was a decrease in the concentration of testosterone and an increase in the testosterone-estradiol binding capacity (TEBC) in men and an increase in the concentration of testosterone and a decrease in TEBC in women. The authors have assumed that the testosterone/TEBC ratio reflects more accurately change in the dynamics of androgens than isolated concentrations of testosterone and TEBG, and recommended its determination for the assessment of the body androgenic saturation in disturbed function of the adrenal or sex glands.
对30名处于活动期的艾兴科-库欣病女性患者、6名处于活动期的艾兴科-库欣病男性患者以及24名患有激素活性肾上腺肿瘤的女性患者，研究了血浆中睾酮和雌二醇的浓度以及睾酮-雌二醇结合球蛋白（TEBG）的结合能力。在皮质醇增多症患者中，血浆雌二醇浓度未变或降低的情况下，男性的睾酮浓度降低，睾酮-雌二醇结合能力（TEBC）增加；女性的睾酮浓度增加，TEBC降低。作者认为，睾酮/TEBC比值比单独的睾酮和TEBG浓度更能准确反映雄激素动态变化，建议测定该比值以评估肾上腺或性腺功能紊乱时体内雄激素的饱和状态。
