Schaison G, Durand F, Mowszowicz I
Ann Endocrinol (Paris). 1979 Jan-Feb;40(1):51-2.
Plasma T and A were studied in 10 patients with hypercorticism. In the female patients, plasma A and T were elevated in 4 cases of Cushing's disease, slightly decreased in 2 cases of adrenal adenoma and greatly increased in I case of adrenal carcinoma. In 3 male patients, A plasma levels followed ACTH levels, but T was subnormal, irrespective of the cause of hypercorticism. Furthermore, in 8 normal men, the decrease of plasma T, observed after ACTH administration, was not directly related to ACTH, but rather to cortisol, as it was not observed after metyrapone induced ACTH increase. As no change in LH secretion was shown and as dexamethasone reduced the testosterone response to HCG, it seems likely that glucocorticoids act directly on testosterone biosynthesis.
对10例皮质醇增多症患者的血浆睾酮（T）和雄烯二酮（A）进行了研究。在女性患者中，4例库欣病患者的血浆A和T升高，2例肾上腺腺瘤患者略有下降，1例肾上腺皮质癌患者大幅升高。在3例男性患者中，无论皮质醇增多症的病因如何，血浆A水平随促肾上腺皮质激素（ACTH）水平变化，但T低于正常水平。此外，在8名正常男性中，注射ACTH后观察到的血浆T降低与ACTH无直接关系，而是与皮质醇有关，因为在甲吡酮诱导ACTH升高后未观察到这种情况。由于促黄体生成素（LH）分泌无变化，且地塞米松降低了睾酮对人绒毛膜促性腺激素（HCG）的反应，糖皮质激素似乎直接作用于睾酮的生物合成。
