“双拳”出击：TIM-3 封锁靶向免疫细胞和肿瘤细胞以消除小儿脑肿瘤。
The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors.
机构信息
Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Case Comprehensive Cancer Center, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor Center, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Cancer Cell. 2023 Nov 13;41(11):1843-1845. doi: 10.1016/j.ccell.2023.09.016. Epub 2023 Oct 19.
Diffuse midline gliomas (DMGs) pose treatment challenges due to their location within the brainstem and invasive nature. Although classical immune checkpoint inhibitors have demonstrated limited success in clinical trials, Ausejo-Mauleon et al. demonstrate TIM-3 is an effective DMG strategy, targeting both immune and tumor cells for dual therapeutic benefit.
弥漫性中线胶质瘤（DMGs）由于位于脑干内且具有侵袭性，因此治疗颇具挑战。虽然经典的免疫检查点抑制剂在临床试验中取得的效果有限，但 Ausejo-Mauleon 等人的研究表明 TIM-3 是一种有效的 DMG 治疗策略，可同时针对免疫细胞和肿瘤细胞进行靶向治疗，实现双重治疗获益。
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