Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Division of Nephrology, Department of Medicine, Landseed International Hospital, Taoyuan, Taiwan.
Clin Chim Acta. 2023 Nov 1;551:117610. doi: 10.1016/j.cca.2023.117610. Epub 2023 Oct 18.
Coronary artery disease (CAD) is a severe comorbidity in chronic kidney disease (CKD) due to heavy calcification in the medial layer and inflamed plaques. Chronic inflammation, endothelial dysfunction and vascular calcification are major contributors that lead to artherosclerosis in CKD. The lack of specific symptoms and signs of CAD and decreased accuracy of noninvasive diagnostic tools result in delayed diagnosis leading to increased mortality. MicroRNAs (miRNAs) are post-transcriptional regulators present in various biofluids throughout the body. In the circulation, miRNAs have been reported to be encapsulated in extracellular vesicles and serve as stable messengers for crosstalk among cells. miRNAs are involved in pathophysiologic mechanisms including CAD and can potentially be extended from basic research to clinical translational practice.
冠状动脉疾病（CAD）是慢性肾脏病（CKD）的一种严重合并症，其原因是中层严重钙化和炎症斑块。慢性炎症、内皮功能障碍和血管钙化是导致 CKD 发生动脉粥样硬化的主要因素。CAD 缺乏特异性症状和体征，且无创性诊断工具的准确性降低，导致诊断延迟，从而增加死亡率。微小 RNA（miRNA）是存在于全身各种生物流体中的转录后调节剂。在循环中，miRNA 被包裹在细胞外囊泡中，作为细胞间通讯的稳定信使。miRNA 参与包括 CAD 在内的病理生理机制，并且有可能从基础研究扩展到临床转化实践。
