Department of Pathology, Faculty of Veterinary Science University of Agriculture, Faisalabad, 38040, Pakistan.
Department of Pathology, Faculty of Veterinary Science University of Agriculture, Faisalabad, 38040, Pakistan.
Toxicon. 2023 Dec;236:107327. doi: 10.1016/j.toxicon.2023.107327. Epub 2023 Oct 19.
Atrazine, a herbicide, is used for eradication of broad-leaved herbs in corn crop; and ochratoxins, particularly ochratoxin A (OTA), are major pollutants of poultry diet. Existence of both of these hazardous chemicals as residues is obvious as elucidated by various epidemiological findings. The present study was designed to investigate toxicopathological, serum biochemical and immunological alterations incurred by atrazine alone and/or, in combination with OTA in broilers. For this purpose, one-day old broiler chicks (n = 180) were purchased from a local hatching unit and were fed two levels of atrazine (50 and 150 mg/kg) and one level of OTA (100 μg/kg) in different combinations. Results of this experiment showed a significant reduction in feed intake, body weight gain, relative organ weights, serum total protein, albumin and globulin while there was a significant increase in urea and creatinine levels, decreased antibody response to sheep red blood cells, reduced lymphoproliferative response and phagocytic capacity in groups given OTA and atrazine individually in feed and these effects became more pronounced when atrazine was given in combination with OTA suggesting synergistic effects of both toxicants for each other.
莠去津，一种除草剂，用于玉米作物中阔叶杂草的清除；而赭曲霉毒素，特别是赭曲霉毒素 A（OTA），是家禽饲料的主要污染物。各种流行病学研究结果表明，这两种危险化学品作为残留物质的存在是显而易见的。本研究旨在研究莠去津单独和/或与 OTA 联合对肉鸡的毒理学、血清生化和免疫学改变。为此，从当地孵化单位购买了 180 只 1 日龄肉鸡，并在不同组合中分别给予莠去津（50 和 150mg/kg）和 OTA（100μg/kg）两个水平。该实验结果表明，饲料摄入量、体重增加、相对器官重量、血清总蛋白、白蛋白和球蛋白显著降低，而尿素和肌酐水平显著升高，对绵羊红细胞的抗体反应降低，淋巴细胞增殖反应和吞噬能力降低，单独给予 OTA 和莠去津的组中出现这些影响，当莠去津与 OTA 联合给予时，这些影响变得更加明显，表明两种毒物之间存在协同作用。
