Department of Pathology, University of California at San Francisco, 505 Parnassus Avenue, M552, Box 0102, San Francisco, CA 94143, USA.
Surg Pathol Clin. 2023 Dec;16(4):687-702. doi: 10.1016/j.path.2023.05.006. Epub 2023 Jun 23.
The term nonconventional dysplasia has been coined to describe several underrecognized morphologic patterns of epithelial dysplasia in inflammatory bowel disease (IBD), but to date, the full recognition of these newly characterized lesions by pathologists is uneven. The identification of nonconventional dysplastic subtypes is becoming increasingly important, as they often present as invisible/flat dysplasia and are more frequently associated with advanced neoplasia than conventional dysplasia on follow-up. This review describes the morphologic, clinicopathologic, and molecular characteristics of seven nonconventional subtypes known to date, as well as their potential significance in the clinical management of IBD patients.
术语“非典型性异型增生”已被用来描述几种在炎症性肠病（IBD）中尚未被充分认识的上皮异型增生形态模式，但迄今为止，病理学家对这些新描述病变的充分认识仍参差不齐。非典型性异型增生亚型的识别变得越来越重要，因为它们通常表现为不可见/平坦型异型增生，并且在随访中比传统异型增生更频繁地与高级别肿瘤相关。本综述描述了迄今为止已知的七种非典型性异型增生亚型的形态学、临床病理学和分子特征，以及它们在 IBD 患者临床管理中的潜在意义。
