Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; Facultad de Medicina, Departamento de Salud, Universidad Nacional de La Matanza, Buenos Aires, Argentina.
Médico Especialista en Psiquiatría y Magister en Neuropsicofarmacología Clínica, IUH, Barceló.
Rev Colomb Psiquiatr (Engl Ed). 2023 Jul-Sep;52(3):265-267. doi: 10.1016/j.rcpeng.2021.06.013. Epub 2023 Oct 18.
Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to withdrawal at a dose of 300 mg per day of zolpidem is presented and a brief review of the literature is carried out.
唑吡坦是一种常用于治疗失眠的非苯二氮䓬类催眠药物，适应证为短期用药。尽管有临床实践证据表明，大量患者多年来一直使用唑吡坦治疗睡眠障碍，但它并不适用于慢性睡眠障碍的治疗。虽然已经描述了它比苯二氮䓬类药物具有更好的不良反应谱，并且比这些药物产生的依赖性和戒断风险更低，但仍有大量关于唑吡坦依赖性和戒断的报告。本文报告了一例因每天服用 300mg 唑吡坦而导致的全身性强直-阵挛性癫痫发作的病例，并对文献进行了简要回顾。
