George J, Hentzschel S, Hünerbein B, König S, Schäfer W
Pharmazie. 1986 Aug;41(8):588-90.
The employment oft microcrystalline cellulose of the Heweten-type (cellulose powder(AB-GDR) for the production of dermatological preparations as aqueous and aqueous-oily multicomponent systems can contribute to the opening of a further field of application of this auxiliary substance in pharmaceutical factories and pharmacies. By means of intensive shearing and mixing forces, e.g. a colloid mill, it is possible to produce dispersions with fluid media, which proved to be stable when they contained a solid content over 8 p.c. Such dispersions can improve the utilization properties of various preparations. By varying the solid content concentration one can produce dispersions of different properties. Microcrystalline cellulose powders meet the demands which characterize an auxiliary substance in general. Special attention has to be drawn on the problem of microbiological stability because of the necessarily high moisture content of the dispersion. Preparations manufactured by colloid wet grinding with microcrystalline cellulose are distinguished by a high physicochemical stability.
将赫韦滕型微晶纤维素（纤维素粉末（AB - GDR））用于生产皮肤科制剂，作为水性和水油多组分体系，这有助于在制药厂和药店开拓这种辅料的新应用领域。通过强力剪切和混合力，如使用胶体磨，可以与流体介质制成稳定的分散体，当固体含量超过8%时，这些分散体被证明是稳定的。这种分散体可以改善各种制剂的使用性能。通过改变固体含量浓度，可以制备出不同性质的分散体。微晶纤维素粉末符合一般辅料的特性要求。由于分散体中必然含有较高水分，所以必须特别关注微生物稳定性问题。用微晶纤维素通过胶体湿法研磨制备的制剂具有很高的物理化学稳定性。
