Jiménez Soriano M M, Fresno Contreras M J, Sellés Flores E
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid, Spain.
Boll Chim Farm. 1996 Jun;135(6):364-73.
Cold-Creams have been used since the times of Galen (II cA.D.) as dermo-pharmaceutical and cosmetic emulsions. This paper proposes a modern Cold-Creams formulation with variations to improve both the formula as well as the properties and applications of the traditional cerates. Basically, a modern self-emulsionable excipient with isopropyl myristate is proposed. This substance is completely analysed from the galenic and pharmaco-technical viewpoints and the analysis is completed with a study of cosmetic or dermo-pharmaceutical effectiveness and topical application on skin. The results clearly show the advantages of the new formula which are: it is easy and comfortable to prepare, very adequate for cosmetology with satisfactory stability and rheological qualities and a high degree of moisture/emollient power make it appropriate as a vehicle for the active principle in Dermopharmacy and Cosmetology.
自盖伦时代（公元2世纪）以来，冷霜就一直被用作皮肤药物和化妆品乳液。本文提出了一种现代冷霜配方，通过改变配方来改进传统蜡膏的配方、性能和应用。基本上，提出了一种含有肉豆蔻酸异丙酯的现代自乳化赋形剂。从药剂学和制药技术的角度对该物质进行了全面分析，并通过对其在皮肤美容或皮肤药物方面的有效性以及局部应用的研究来完成分析。结果清楚地表明了新配方的优点：制备容易且舒适，非常适合美容，具有令人满意的稳定性和流变学性质，高度的保湿/润肤能力使其适合作为皮肤药物学和美容学中活性成分的载体。
