Proposal and pharmacotechnical study of a modern dermo-pharmaceutical formulation for cold cream.

Cold-Creams have been used since the times of Galen (II cA.D.) as dermo-pharmaceutical and cosmetic emulsions. This paper proposes a modern Cold-Creams formulation with variations to improve both the formula as well as the properties and applications of the traditional cerates. Basically, a modern self-emulsionable excipient with isopropyl myristate is proposed. This substance is completely analysed from the galenic and pharmaco-technical viewpoints and the analysis is completed with a study of cosmetic or dermo-pharmaceutical effectiveness and topical application on skin. The results clearly show the advantages of the new formula which are: it is easy and comfortable to prepare, very adequate for cosmetology with satisfactory stability and rheological qualities and a high degree of moisture/emollient power make it appropriate as a vehicle for the active principle in Dermopharmacy and Cosmetology.