Totten Melissa S, Howell Jenna M, Tomberlin Jordan A, Erikson Keith M
Department of Chemistry and Physics, Salem College, Winston-Salem, NC, USA.
Department of Biology, Salem College, Winston-Salem, NC, USA.
Biol Trace Elem Res. 2024 Jul;202(7):3215-3224. doi: 10.1007/s12011-023-03911-w. Epub 2023 Oct 21.
The dysregulation of trace elements in the brain, which can be caused by genetic or environmental factors, has been associated with disease and compromised mobility. Research regarding trace elements and motor function has focused mainly on the basal ganglia, but few studies have examined the olfactory bulb in this context. Diets high in fat have been shown to have consequences of dysregulated iron and manganese in the brain and disrupted motor activity. The aim of our study was to examine the relationship between mobility and trace element disruption in the olfactory bulb in male and female C57BL/6J and DBA/2J mice fed a high-fat diet. Mobility was significantly reduced in male C57BL/6Js, but the correlation between iron and manganese in the olfactory bulb with velocity, distance travelled, and habituation was not statistically significant. However, there appears to be an overall pattern of a high-fat diet having a statistically significant impact individually on elevated iron and manganese in the olfactory bulb, reduced velocity, reduced distance travelled, and reduced habituation mainly in the male C57BL/6J strain. We found similar trends within the scientific literature to suggest that dysregulated trace element status in the olfactory bulb may be related to motor function in both humans and animals and that males may be more susceptible to the negative outcomes. Our findings contribute new information regarding the impact of diet on the brain, behavior, and potential connection between trace element dysregulation in the olfactory bulb with mobility.
大脑中微量元素的失调可能由遗传或环境因素引起，与疾病和运动能力受损有关。关于微量元素与运动功能的研究主要集中在基底神经节，但在这种情况下，很少有研究考察嗅球。高脂肪饮食已被证明会导致大脑中铁和锰的失调以及运动活动的紊乱。我们研究的目的是考察在喂食高脂肪饮食的雄性和雌性C57BL/6J和DBA/2J小鼠中，嗅球中微量元素紊乱与运动能力之间的关系。雄性C57BL/6J小鼠的运动能力显著降低，但嗅球中铁和锰与速度、行进距离和习惯化之间的相关性在统计学上并不显著。然而，高脂肪饮食似乎总体上对嗅球中铁和锰升高、速度降低、行进距离减少以及习惯化减少有统计学上的显著影响，主要发生在雄性C57BL/6J品系中。我们在科学文献中发现了类似的趋势，表明嗅球中微量元素状态失调可能与人类和动物的运动功能有关，而且雄性可能更容易受到负面结果的影响。我们的研究结果提供了关于饮食对大脑、行为以及嗅球中微量元素失调与运动能力之间潜在联系影响的新信息。
