Department of Urology, School of Medicine, Nigde Omer Halisdemir University, Niğde, Türkiye.
Dokuz Eylül University School of Medicine, Department of Urology, Izmir, Türkiye.
Int J Impot Res. 2024 Jun;36(4):339-347. doi: 10.1038/s41443-023-00777-3. Epub 2023 Oct 20.
This study aimed to review the current knowledge on sexual dysfunction in men and women with hyperthyroidism through a systematic review and meta-analysis. Available clinical trials from the MEDLINE database were searched using a prerecorded protocol (Protocol Prospero ID: CRD42022340587), and obtained data were analyzed and reported according to the PRISMA guidelines. Pooled effect estimates were computed using a random-effects model. Twenty eligible studies were identified, of which 15 were included in this meta-analysis. The prevalence of erectile dysfunction was significantly higher in participants with hyperthyroidism than that in controls [odds ratio = 9.16 (95% confidence interval [CI], 5.0-16.5)]. Treatment of hyperthyroidism alone improved erectile functions [effect size, ES = 0.36 (95% CI, -0.01-72)] and mean intra-vaginal ejaculation latency time [ES = 0.63 (95% CI, 0.27-98)] among men with erectile dysfunction and/or premature ejaculation. The prevalence of premature ejaculation also decreased with treatment of hyperthyroidism [odds ratio = 0.11 (95% CI, 0.04-28). Women with hyperthyroidism demonstrated higher odds in female sexual dysfunction than controls [odds ratio = 4.34 (95% CI, 2.63-7.18)]. Female sexual function index scores in women with hyperthyroidism were also significantly lower than those in the controls with moderate effect sizes. An evident and reversible disruption of sexual functions under hyperthyroidism conditions was observed in both sexes.
本研究旨在通过系统回顾和荟萃分析，综述甲状腺功能亢进症患者的性功能障碍的现有知识。使用预先录制的方案（Prospéro 注册号：CRD42022340587）检索 MEDLINE 数据库中的现有临床试验，并根据 PRISMA 指南分析和报告获得的数据。使用随机效应模型计算合并效应估计值。确定了 20 项符合条件的研究，其中 15 项研究纳入本荟萃分析。与对照组相比，甲状腺功能亢进症患者的勃起功能障碍患病率显著更高[比值比=9.16（95%置信区间 [CI]，5.0-16.5)]。单纯治疗甲状腺功能亢进症可改善勃起功能障碍[效应量，ES=0.36（95%CI，-0.01-72）]和男性早泄[ES=0.63（95%CI，0.27-98）]患者的平均阴道内射精潜伏期。甲状腺功能亢进症的治疗还可降低早泄的患病率[比值比=0.11（95%CI，0.04-28)]。与对照组相比，甲状腺功能亢进症女性发生女性性功能障碍的几率更高[比值比=4.34（95%CI，2.63-7.18)]。甲状腺功能亢进症女性的女性性功能指数评分也显著低于对照组，具有中度效应大小。在两性中，均观察到甲状腺功能亢进症状态下性功能的明显且可逆的紊乱。
