Department of Urology, University of Health Sciences, Okmeydani Training & Research Hospital, Istanbul, Turkey.
Department of Urology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, Istanbul, Turkey.
Int J Impot Res. 2020 May;32(3):352-357. doi: 10.1038/s41443-019-0188-x. Epub 2019 Sep 3.
Although premature ejaculation (PE) is a common male sexual dysfunction, its pathophysiology has not been fully elucidated. Several medical problems such as erectile dysfunction, depression, anxiety, hormonal disorders and chronic prostatitis may play a role in the etiology of acquired PE. This study aims to evaluate the frequency of these etiologic factors among patients with acquired PE. Between May and July 2016, 53 men with acquired PE were included in the study. Self-estimated intravaginal ejaculation latency time (IELT) of these patients was recorded along with their medical history and physical examination findings. Moreover, 5-item version of the International Index of Erectile Function (IIEF-5), premature ejaculation profile (PEP), anxiety and depression scales (STAI-1, STAI-2, and BECK), and chronic prostatitis symptom index (NIH-CPSI) were administered. Fasting plasma glucose, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total and free testosterone, total prostate specific antigen, thyroid and thyroid stimulating hormone levels were measured. Urine analysis and 2 cup tests were also studied. Mean age of the patients was 42.41 ± 11.14 (22-60). Mean duration of the PE complaint was 34.18 ± 36.76 (3-144) months. Mean IELT time of the patients was 38.28 ± 30.79 (3-180) s. Of the patients; 69.81%, 62.26%, 56.60%, 45.28%, 30.19%, 24.53%, 16.98%, 15.09%, and 7.55% had depression, chronic prostatitis, erectile dysfunction, anxiety, diabetes mellitus, abnormal FSH or LH, hypoprolactinemia, hyperthyroidism, and high testosterone levels, respectively. The results of our study revealed that anxiety disorders, depression, erectile dysfunction, and chronic prostatitis are common among patients with acquired PE and may play role in the etiology of this problem. There is a need for further researches related to the exact pathophysiology of acquired PE with larger number of patients.
虽然早泄（PE）是一种常见的男性性功能障碍，但它的病理生理学尚未完全阐明。一些医学问题，如勃起功能障碍、抑郁、焦虑、激素紊乱和慢性前列腺炎，可能在获得性 PE 的病因中起作用。本研究旨在评估这些病因因素在获得性 PE 患者中的频率。2016 年 5 月至 7 月期间，纳入 53 名获得性 PE 患者。记录这些患者的自我估计阴道内射精潜伏期时间（IELT），并记录他们的病史和体格检查结果。此外，还进行了 5 项国际勃起功能指数（IIEF-5）、早泄概况（PEP）、焦虑和抑郁量表（STAI-1、STAI-2 和 BECK）以及慢性前列腺炎症状指数（NIH-CPSI）的评估。测量了空腹血糖、卵泡刺激素（FSH）、黄体生成素（LH）、催乳素、总睾酮和游离睾酮、总前列腺特异性抗原、甲状腺和甲状腺刺激素水平。还进行了尿液分析和 2 杯测试。患者的平均年龄为 42.41±11.14 岁（22-60 岁）。PE 抱怨的平均持续时间为 34.18±36.76 个月（3-144 个月）。患者的平均 IELT 时间为 38.28±30.79 秒（3-180 秒）。患者中，69.81%、62.26%、56.60%、45.28%、30.19%、24.53%、16.98%、15.09%和 7.55%分别患有抑郁症、慢性前列腺炎、勃起功能障碍、焦虑症、糖尿病、FSH 或 LH 异常、低催乳素血症、甲状腺功能亢进和高睾酮血症。我们的研究结果表明，焦虑症、抑郁症、勃起功能障碍和慢性前列腺炎在获得性 PE 患者中很常见，可能在该问题的病因中起作用。需要进一步开展更多患者的相关研究，以明确获得性 PE 的确切病理生理学。
