Yin Yangxue, Xie Shuangshuang, Xu Qin, Liao Lingyun, Chen Hongqin, Zhou Rong
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, No. 20, section 3, Renmin South Road, Wuhou District, Chengdu, Sichuan, 610041, China.
NHC Key Laboratory of Chronobiology, Sichuan University, Chengdu, China.
Lipids Health Dis. 2023 Oct 20;22(1):179. doi: 10.1186/s12944-023-01941-w.
Preeclampsia (PE) is a new-onset pregnancy-specific disorder with a high prevalence that leads to over 70 000 maternal and 500 000 foetal fatalities worldwide each year. The level of chemerin, a newly identified adipokine, is increased in diabetic and obese patients. Currently, there are several studies describing the relationship between maternal circulating chemerin levels and PE. Therefore, this study aimed to assess their association in pooled samples.
Four databases were systematically searched to identify potential studies that reported circulating chemerin levels in PE and normal pregnancy groups. Standardized mean differences (SMDs), 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated using a random-effects meta-analysis. The probability of heterogeneity was also investigated by sensitivity analysis, subgroup analysis, and meta-regression.
Thirteen studies in 11 articles with a total of 860 PE patients and 1309 women with normal pregnancies met the inclusion criteria. The results of the meta-analysis revealed that circulating chemerin, which levels in PE patients were considerably higher than those in controls (SMD = 1.39, 95% CI: 1.02, 1.77, 95% PI: -0.07, 2.86). Moreover, sensitivity analysis determined that the outcomes of the overall pooled results were not affected after the elimination of any study. Notably, subgroup analysis demonstrated a similar expression pattern irrespective of geographic location, severity, timing of sampling, and sample size. Last, there were no factors that significantly impacted the overall estimate, according to meta-regression.
This meta-analysis is the first to assess circulating chemerin levels in PE patients. The findings indicate that circulating chemerin levels may be a potential marker to diagnose PE.
子痫前期（PE）是一种新出现的妊娠特异性疾病，患病率高，每年在全球导致超过70000例孕产妇死亡和500000例胎儿死亡。趋化素是一种新发现的脂肪因子，在糖尿病和肥胖患者中水平升高。目前，有多项研究描述了母体循环趋化素水平与子痫前期之间的关系。因此，本研究旨在评估合并样本中它们之间的关联。
系统检索四个数据库，以确定报告子痫前期组和正常妊娠组循环趋化素水平的潜在研究。使用随机效应荟萃分析计算标准化均值差（SMD）、95%置信区间（CI）和95%预测区间（PI）。还通过敏感性分析、亚组分析和荟萃回归研究异质性的概率。
11篇文章中的13项研究共纳入860例子痫前期患者和1309例正常妊娠女性，符合纳入标准。荟萃分析结果显示，子痫前期患者循环趋化素水平显著高于对照组（SMD = 1.39，95%CI：1.02，1.77，95%PI：-0.07，2.86）。此外，敏感性分析确定，剔除任何一项研究后，总体合并结果不受影响。值得注意的是，亚组分析表明，无论地理位置、严重程度、采样时间和样本量如何，表达模式相似。最后，根据荟萃回归，没有因素对总体估计有显著影响。
这项荟萃分析首次评估了子痫前期患者的循环趋化素水平。研究结果表明，循环趋化素水平可能是诊断子痫前期的潜在标志物。
