多囊卵巢综合征患者循环中 apelin 和 chemerin 水平：一项荟萃分析。
Circulating apelin and chemerin levels in patients with polycystic ovary syndrome: A meta-analysis.
机构信息
The First Clinical College of China Medical University, Shenyang, China.
Department of Endocrinology and Metabolism, The Fourth People's Hospital of Shenyang, Shenyang, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jan 11;13:1076951. doi: 10.3389/fendo.2022.1076951. eCollection 2022.
BACKGROUND
Polycystic ovary syndrome (PCOS) is one of the most common gynecological endocrine disorders. Apelin and chemerin are newly identified adipokines, which are higher in obesity and diabetes. Studies have found that the serum apelin and chemerin levels in patients with PCOS are significantly increased. However, other studies showed the opposite results. Therefore, the relationship between those two adipokines and PCOS is still controversial.
AIM
This meta-analysis was conducted to statistically evaluate the apelin and chemerin levels of patients with PCOS.
METHODS
We searched the Web of Science, Embase, PubMed, and Google Scholar databases for potential studies. "Polycystic ovary syndrome" or "PCOS" in combination with the terms "apelin" or "chemerin" were used as keywords search titles or abstracts. The publication period examined was between 1990 and 2021. Standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were determined as the results of the meta-analysis.
RESULTS
A total of 148 articles were initially retrieved, and 18 qualified articles were finally obtained through preliminary screening and quality evaluation. The publications together contain 1,265 cases and 894 controls. The results of the meta-analysis showed that the circulating chemerin levels in patients with PCOS were significantly higher than those in the controls (SMD: 0.79, 95% CI [0.36, 1.23]), and there was no significant difference in circulating apelin between patients with PCOS and controls (SMD: 0.57, 95% CI [-0.21, 1.35]).
CONCLUSIONS
This meta-analysis is the first to evaluate circulating apelin and chemerin levels in patients with PCOS. Our findings suggest that circulating chemerin levels of patients with PCOS are significantly higher than those of healthy controls.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=218316, identifier CRD42020218316.
背景
多囊卵巢综合征（PCOS）是最常见的妇科内分泌疾病之一。Apelin 和 Chemerin 是新发现的脂肪因子，在肥胖和糖尿病患者中水平升高。研究发现，PCOS 患者血清 Apelin 和 Chemerin 水平显著升高。然而，其他研究则得出了相反的结果。因此，这两种脂肪因子与 PCOS 的关系仍存在争议。
目的
本荟萃分析旨在对 PCOS 患者的 Apelin 和 Chemerin 水平进行统计学评估。
方法
我们检索了 Web of Science、Embase、PubMed 和 Google Scholar 数据库，以寻找潜在的研究。使用“多囊卵巢综合征”或“PCOS”与 Apelin 或 Chemerin 等术语相结合作为关键词搜索标题或摘要。检查的出版时间为 1990 年至 2021 年。标准化均数差（SMD）及其相应的 95%置信区间（CI）被确定为荟萃分析的结果。
结果
共检索到 148 篇文章，通过初步筛选和质量评价，最终获得 18 篇合格文章。这些出版物共包含 1265 例病例和 894 例对照。荟萃分析结果显示，PCOS 患者的循环 Chemerin 水平明显高于对照组（SMD：0.79，95%CI [0.36，1.23]），而 PCOS 患者与对照组的循环 Apelin 水平无显著差异（SMD：0.57，95%CI [-0.21，1.35]）。
结论
这是首次评估 PCOS 患者循环 Apelin 和 Chemerin 水平的荟萃分析。我们的研究结果表明，PCOS 患者的循环 Chemerin 水平明显高于健康对照组。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=218316，标识符 CRD42020218316。
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