Sivri Fatih, Türköz Ismail, Şencan Mehtap, İçen Yahya Kemal, Aksoy Fatih, Ceyhan Banu Öztürk
Aydin Nazilli State Hospital, Nazilli, Turkey.
Department of Infectious Diseases, Dortyol State Hospital, Hatay, Turkey.
Angiology. 2025 Mar;76(3):257-263. doi: 10.1177/00033197231209584. Epub 2023 Oct 20.
Coronavirus disease 2019 (COVID-19) remains a health problem worldwide. The present study aimed to investigate the effect of blood pressure (BP) on the circadian pattern and prevalence of new-onset non-dipper hypertension in the post-COVID period in patients with known hypertension. This prospective single-center study included 722 patients hospitalized for COVID-19 infection. Ambulatory BP (ABP) data were collected during their initial hospitalization. The ABP data were reassessed 1 month after the patients were discharged. The results were compared with a healthy control group with known hypertension but without COVID-19 infection. After exclusion criteria were applied, the study included 187 patients with COVID-19 and 136 healthy hypertensive controls. Post-COVID ABP showed that patients with COVID-19 had significantly higher mean 24-h systolic and diastolic BP, mean nighttime systolic and diastolic BP, and mean daytime diastolic BP than the control group. In addition, new-onset non-dipper hypertension was significantly higher in patients with COVID-19. This study demonstrated for the first time that the circadian pattern is disturbed and a non-dipper pattern develops in individuals with known hypertension during the post-COVID period.
2019冠状病毒病（COVID-19）仍是一个全球性的健康问题。本研究旨在调查血压（BP）对已知高血压患者COVID-19康复期新发非杓型高血压的昼夜模式和患病率的影响。这项前瞻性单中心研究纳入了722例因COVID-19感染住院的患者。在他们初次住院期间收集动态血压（ABP）数据。患者出院1个月后重新评估ABP数据。将结果与一组已知患有高血压但未感染COVID-19的健康对照组进行比较。应用排除标准后，该研究纳入了187例COVID-19患者和136例健康高血压对照组。COVID-19康复期的ABP显示，COVID-19患者的24小时平均收缩压和舒张压、夜间平均收缩压和舒张压以及日间平均舒张压均显著高于对照组。此外，COVID-19患者新发非杓型高血压的比例显著更高。本研究首次证明，在COVID-19康复期，已知高血压患者的昼夜模式受到干扰，出现非杓型模式。
