基于血红素的直接氧感应蛋白对细菌第二信使信号和运动的控制。

Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins.

机构信息

Department of Chemistry, Penn State University, University Park, PA 16802, USA.

Department of Chemistry, Penn State University, University Park, PA 16802, USA; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA 16802, USA.

出版信息

Curr Opin Microbiol. 2023 Dec;76:102396. doi: 10.1016/j.mib.2023.102396. Epub 2023 Oct 19.

DOI:10.1016/j.mib.2023.102396

PMID:37864983

Abstract

Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.

摘要

细菌能够感知和响应其环境，使它们能够在氧气水平等变化条件下最大限度地生存和生长。直接的氧气感应蛋白允许细菌快速感知浓度变化，并通过调节信号通路和/或细胞机制来适应。最近的工作已经确定了直接氧气感应蛋白在控制第二信使水平和运动机制以及对生物膜形成、毒力和运动性的影响中的作用。在这篇综述中，我们讨论了理解 O 依赖的环二鸟苷酸信号和运动性调节的最新进展，并强调了控制细菌生理学和行为的重要性。