College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Theriogenology. 2024 Jan 15;214:98-106. doi: 10.1016/j.theriogenology.2023.10.019. Epub 2023 Oct 17.
Extracellular adenosine 5'-triphosphate (ATP) is a vital signaling molecule involved in various physiological processes within the body. In recent years, studies have revealed its significant role in male reproduction, particularly in sperm function. This review explores the multifaceted role of extracellular ATP in sperm function, from spermatogenesis to fertilization. We discuss the impact of extracellular ATP on spermatogenesis, sperm maturation and sperm-egg fusion, highlighting the complex regulatory mechanisms and potential clinical applications in the context of male infertility. By examining the latest research, we emphasize the crucial role of extracellular ATP in sperm function and propose future research directions to further.
细胞外三磷酸腺苷（ATP）是一种重要的信号分子，参与体内的各种生理过程。近年来，研究揭示了它在男性生殖中的重要作用，特别是在精子功能方面。本文综述了细胞外 ATP 在精子功能中的多方面作用，从精子发生到受精。我们讨论了细胞外 ATP 对精子发生、精子成熟和精卵融合的影响，强调了复杂的调节机制以及在男性不育症中的潜在临床应用。通过检查最新的研究，我们强调了细胞外 ATP 在精子功能中的关键作用，并提出了进一步研究的方向。
