University of Wisconsin School of Medicine and Public Health, University of Wisconsin in Madison, Madison, WI, USA.
Mol Ther. 2023 Nov 1;31(11):3117-3118. doi: 10.1016/j.ymthe.2023.10.010. Epub 2023 Oct 20.
The mechanistically defined attributes of primed MSCs as here described not only provide a novel use case of MIF activated MSCs that can address the potency shortcomings of generic culture-adapted MSCs for acute lung injury but also provide some intriguing "Rosetta Stone" insights on plausible in vivo physiology of MSCs with host innate effectors such as macrophages in response to inflammation.
这里所描述的被预先激活的间充质干细胞的机制定义属性不仅为 MIF 激活的间充质干细胞提供了一个新的应用案例，可解决普通培养适应的间充质干细胞在急性肺损伤中的效力不足问题，而且还为间充质干细胞与宿主先天效应细胞（如巨噬细胞）在炎症反应中可能的体内生理学提供了一些有趣的“罗塞塔石碑”见解。
