Mitchell G M, Frykman G K, Morrison W A, O'Brien B M
Plast Reconstr Surg. 1986 Dec;78(6):801-10. doi: 10.1097/00006534-198678060-00016.
To determine the end point of histopathologic damage in avulsed arteries, the forearm arteries of five monkeys being sacrificed were avulsed longitudinally and samples of proximal and distal arteries prepared for light microscopy and transmission and scanning electron microscopy. A severe and consistent circumferential skip lesion was found on the luminal surface involving the intima and media. In 30 percent of vessels, histopathologic damage extended more than 3.0 cm from the rupture point. Similar circumferential tears occurred on the luminal surface of resected human avulsed arteries collected at the time of replantation surgery. No consistent lesions were noted in resected veins from human avulsed amputations. It is possible that in the human artery (as in the monkey) circumferential lesions frequently extend many centimeters from the rupture point and therefore beyond resection distances. Lesions present in the vessel after resection and microsurgical repair might be the site of thrombosis and subsequent occlusion.
为确定离断动脉组织病理学损伤的终点，对五只即将处死的猴子的前臂动脉进行纵向离断，并制备近端和远端动脉样本用于光学显微镜、透射电子显微镜和扫描电子显微镜检查。在管腔表面发现了严重且一致的环形跳跃性病变，累及内膜和中膜。在30%的血管中，组织病理学损伤从破裂点延伸超过3.0厘米。在再植手术时收集的离断的人类动脉的管腔表面也出现了类似的环形撕裂。在离断截肢的人类静脉切除标本中未发现一致的病变。在人类动脉中（如同在猴子中一样），环形病变可能经常从破裂点延伸数厘米，因此超出了切除范围。切除和显微外科修复后血管中存在的病变可能是血栓形成及随后闭塞的部位。
