Department of Surgery, Center for Fetal Research, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA.
Division of Surgical Research, Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN.
Tech Vasc Interv Radiol. 2023 Jun;26(2):100894. doi: 10.1016/j.tvir.2023.100894. Epub 2023 Aug 6.
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially fatal condition. Despite existing treatments, recurrence rates and complications remain high. Understanding the pathophysiology of thrombus formation is crucial for developing effective therapies. This narrative review provides an overview of the critical elements of acute and chronic DVT, presents a theoretical framework for understanding thrombus formation, and discusses potential implications for therapeutic interventions. In addition, a hypothesis of thrombus formation is formulated, encompassing all elements described in this work.
静脉血栓栓塞症（VTE），包括深静脉血栓形成（DVT）和肺栓塞（PE），是一种常见且可能致命的疾病。尽管已有治疗方法，但复发率和并发症仍居高不下。了解血栓形成的病理生理学对于开发有效的治疗方法至关重要。本综述概述了急性和慢性 DVT 的关键要素，提出了一个理解血栓形成的理论框架，并讨论了对治疗干预的潜在影响。此外，还提出了一个血栓形成的假说，包含了本工作中描述的所有要素。
