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[健康受试者单次服用精神药物的定量脑电图分析]

[Quantitative EEG analysis of a single dose of psychotropic drugs in healthy probands].

作者信息

Fischer W, Streubel F R, Heydenreich F, Rabending G

出版信息

Psychiatr Neurol Med Psychol (Leipz). 1986 Aug;38(8):450-5.

PMID:3786575
Abstract

In a series of 74 experiments in a double blind study, 25 healthy test persons were medicated with a single dose of Clomipramin, Desipramin, Imipramin, Diazepam, Carbamazepin, Haloperidol, and a placebo. At the end of one hour, and again at the end of three hours, an EEG was made whose frequency analysis revealed significant changes in about half the test persons. The antidepressives induced an increase in the theta waves, the slow alpha waves, and the slow beta waves, and a decrease in the fast alpha waves. The factors influencing the EEG are discussed.

摘要

在一项双盲研究的74次实验中,25名健康受试者分别单次服用氯米帕明、地昔帕明、丙咪嗪、地西泮、卡马西平、氟哌啶醇和安慰剂。在1小时结束时以及再次在3小时结束时,进行了脑电图检查,其频率分析显示约一半的受试者有显著变化。抗抑郁药导致θ波、慢α波和慢β波增加,快α波减少。讨论了影响脑电图的因素。

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