MMPI profiles in anorexia nervosa patients with and without major depression.

Anorexia nervosa patients with (AN-RDC+) and without (AN-RDC-) a current episode of nonbipolar major depression (MDD) differed with respect to their Minnesota Multiphasic Personality Inventory (MMPI) profiles. Mean MMPI scores in AN-RDC+ significantly differed from AN-RDC-patients in all but two MMPI scales. AN-RDC+ patients had a significantly higher number of abnormal (T greater than 70) MMPI scales per subject and significantly more subjects with greater than or equal to 3 abnormal scales compared with AN-RDC-patients. These MMPI data suggest that the presence or absence of MDD in anorectic patients may distinguish meaningful subtypes and provide further support for the validity of the stratification of anorectic patients into those with and without nonbipolar MDD.