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胸腔镜补丁修补先天性膈疝:较小的切口能治疗更大的缺陷吗?

Thoracoscopic Patch Repair of Congenital Diaphragmatic Hernia: Can Smaller Incisions Treat Larger Defects?

机构信息

University of Michigan, Michigan Medicine, Department of Surgery, Section of Pediatric Surgery, C.S. Mott Children's Hospital, 1540 E. Hospital Dr., Ann Arbor, MI 48109-4211, USA.

Nationwide Children's Hospital, Department of Surgery, Section of Pediatric Surgery, 700 Childrens Dr., Columbus, OH 43205, USA.

出版信息

J Pediatr Surg. 2024 Jun;59(6):1083-1088. doi: 10.1016/j.jpedsurg.2023.09.040. Epub 2023 Sep 29.

Abstract

INTRODUCTION

Thoracoscopic CDH repair is increasingly performed for Type A and small Type B defects that are amenable to primary repair. However, the thoracoscopic approach is controversial for larger defects necessitating a patch due to technical complexity, intraoperative acidosis, and recurrence risk. We aim to compare clinical outcomes between thoracoscopic and open patch repair of Type B/C defects, using a standardized technique.

METHODS

This is a single-center retrospective review of thoracoscopic and open CDH patch repairs January 2017-December 2021. We excluded primary repairs, Type D hernias, repairs on ECMO, recurrent repairs. Various preoperative, intraoperative, and postoperative variables were compared. Primary outcome was recurrence rate. Secondary outcomes included intraoperative pH and pCO, operative time, and complication rates.

RESULTS

Twenty-nine patients met inclusion criteria (open = 13, thoracoscopic = 16). The open cohort had lower o/e total fetal lung volume (29 vs 41.2%, p = 0.042), higher preoperative peak inspiratory pressures (24 vs 20 cm HO, p = 0.007), were more frequently Type C defects (92.3 vs 31%, p = 0.002) and had liver "up" in left-sided hernias (46 vs 0%, p < 0.0001). Intraoperatively, median lowest pH and highest pCO did not differ; neither did overall median pH or pCO. Operative times were similar (153 vs 194 min, p = 0.113). No difference in recurrence rates was identified, however postoperative complications were higher in the open group. There were no mortalities.

CONCLUSIONS

Although we demonstrate higher disease severity of patients undergoing open repair, thoracoscopic patch repair for Type B/C defects is safe and effective in patients with favorable physiologic status, alleviating concerns for intraoperative acidosis, operative length, and risk of recurrence.

LEVEL OF EVIDENCE

II.

摘要

简介

胸腔镜 CDH 修复术越来越多地用于 A 型和 B 型小缺陷的治疗,这些缺陷适合进行一期修复。然而,对于需要修补的较大缺陷,由于技术复杂性、术中酸中毒和复发风险,胸腔镜方法存在争议。我们旨在比较使用标准化技术进行胸腔镜和开放式 B/C 型缺陷修补的临床结果。

方法

这是一项回顾性单中心研究,纳入了 2017 年 1 月至 2021 年 12 月期间进行的胸腔镜和开放性 CDH 修补术。我们排除了原发性修复、D 型疝、ECMO 上的修复、复发性修复。比较了各种术前、术中及术后变量。主要结局是复发率。次要结局包括术中 pH 值和 pCO2、手术时间和并发症发生率。

结果

29 例患者符合纳入标准(开放组 13 例,胸腔镜组 16 例)。开放组的胎儿总肺容积比(o/e)更低(29%比 41.2%,p=0.042),术前吸气峰压更高(24cm HO 比 20cm HO,p=0.007),更常见 C 型缺陷(92.3%比 31%,p=0.002),左侧疝中肝脏“向上”(46%比 0%,p<0.0001)。术中,最低 pH 值和最高 pCO2的中位数无差异;总体 pH 值或 pCO2的中位数也无差异。手术时间相似(153 分钟比 194 分钟,p=0.113)。未发现复发率的差异,但开放组术后并发症更高。无死亡病例。

结论

尽管我们发现接受开放修复的患者疾病严重程度更高,但对于生理状态良好的 B/C 型缺陷患者,胸腔镜修补术是安全有效的,可以缓解对术中酸中毒、手术时间和复发风险的担忧。

证据水平

II 级。

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