Grossman R I, Gonzalez-Scarano F, Atlas S W, Galetta S, Silberberg D H
Radiology. 1986 Dec;161(3):721-5. doi: 10.1148/radiology.161.3.3786722.
Magnetic resonance (MR) images--both nonenhanced and enhanced with gadolinium DTPA/dimeglumine (Gd)--were compared with high-iodine (88.1 g I) computed tomographic (HICT) scans in demonstrating lesions in 15 patients known to have multiple sclerosis (MS). T1-weighted, mixed (T1, proton density, and T2), and T2-weighted MR pulse sequences were used. More than 20 lesions in each of 14 patients were demonstrated by pre-Gd mixed images and T2WI. Nine patients had clinical symptoms of active disease. Gd-enhanced T1WI showed at least one lesion that appeared to correspond with newly reported symptoms or signs. In addition, three clinically stable patients showed enhancement. Enhancement was best seen on 3-minute T1WI. HICT scans showed enhancement in four of the nine patients with active disease and in none of five clinically stable patients. Gd-enhanced MR imaging appears to be more sensitive than HICT in the detection of the transient abnormalities of the blood-brain barrier that occur in patients with active MS and appears capable of distinguishing active lesions that may correspond to the anatomic regions responsible for abnormal clinical findings.
在15例已知患有多发性硬化症（MS）的患者中，对磁共振（MR）图像（包括未增强的和用钆喷酸葡胺/葡甲胺（Gd）增强的）与高碘（88.1 g碘）计算机断层扫描（HICT）进行了比较，以显示病变情况。使用了T1加权、混合（T1、质子密度和T2）以及T2加权的MR脉冲序列。14例患者中，Gd增强前的混合图像和T2WI均显示出20多个病变。9例患者有疾病活动的临床症状。Gd增强的T1WI显示至少一个病变似乎与新出现的症状或体征相对应。此外，3例临床稳定的患者也有强化表现。在3分钟的T1WI上强化表现最为明显。HICT扫描显示，9例疾病活动患者中有4例出现强化，而5例临床稳定患者均未出现强化。Gd增强的MR成像在检测活动性MS患者血脑屏障的短暂异常方面似乎比HICT更敏感，并且似乎能够区分可能与导致异常临床发现的解剖区域相对应的活动性病变。
