Laboratory of Bioeconomics, Food Safety and Health, Faculty of Natural Sciences and Life, University of Abdelhamid Ibn Badis, Mostaganem, Algeria.
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Libre University of Brussels, Brussels, Belgium.
Nat Prod Res. 2024 Nov;38(22):4017-4027. doi: 10.1080/14786419.2023.2272283. Epub 2023 Oct 22.
This study investigated the effect of roots etheric extract (UDEE) on oxidative stress, and urine obstruction with histopathological examinations of prostatic and renal tissues,and suggests computational methods as a complementary method, to make a hypothesis on the overall effect of UDEE in the treatment of benign prostatic hyperplasia (BPH).Gas chromatography/mass spectrometry was utilised to characterise UDEE.BPH was induced in rats through daily subcutaneous injections of testosterone propionate. Rats were also orally administered UDEE or a vehicle. After four weeks, prostate weight, urine output, and biochemical markers were evaluated. UDEE treatment demonstrated significant regression of prostatic enlargement, improved biochemical and histopathological characteristics, and regulation of antioxidant activity levels. Phytosteroids stand out, act by inhibiting 5α-reductase and aromatase. This study provides an insight into treatment of BPH, demonstrating safety of this compound towards the kidney compared to finasteride without severe side effects.
本研究探讨了根醚提取物（UDEE）对氧化应激和尿路梗阻的影响，并对前列腺和肾脏组织进行了组织病理学检查，同时提出计算方法作为一种补充方法，对 UDEE 在治疗良性前列腺增生（BPH）中的整体作用做出假设。利用气相色谱/质谱联用技术对 UDEE 进行了表征。通过每日皮下注射丙酸睾酮诱导大鼠发生 BPH，同时大鼠经口给予 UDEE 或载体。四周后，评估前列腺重量、尿排量和生化标志物。UDEE 治疗可显著缩小前列腺肿大，改善生化和组织病理学特征，并调节抗氧化活性水平。植物甾醇尤为突出，通过抑制 5α-还原酶和芳香酶起作用。本研究为 BPH 的治疗提供了新的思路，与非那雄胺相比，UDEE 对肾脏的安全性更高，且没有严重的副作用。
