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星形胶质细胞——神经退行性疾病的敌是友?

Astrocytes - friends or foes in neurodegenerative disorders.

机构信息

Discipline of Anatomy, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;

出版信息

Rom J Morphol Embryol. 2023 Jul-Sep;64(3):305-309. doi: 10.47162/RJME.64.3.02.

DOI:10.47162/RJME.64.3.02
PMID:37867348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10720932/
Abstract

Astrocytes (AS) are the most abundant glial cells in the central nervous system (CNS). They have various morphologies and numerous (50-60) branching prolongations, with roles in the maintenance of the CNS function and homeostasis. AS in the optic nerve head (ONH) have specific distribution and function and are involved in the pathogenesis of glaucoma and other neural diseases, modify their morphologies, location, immune phenotype, and ultrastructure, thus being the key players in the active remodeling processes of the ONH.

摘要

星形胶质细胞(AS)是中枢神经系统(CNS)中最丰富的神经胶质细胞。它们具有各种形态和许多(50-60)分支延伸,在维持 CNS 功能和内稳态方面发挥作用。视神经头(ONH)中的 AS 具有特定的分布和功能,参与青光眼和其他神经疾病的发病机制,改变其形态、位置、免疫表型和超微结构,因此是 ONH 主动重塑过程中的关键参与者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/c17044aaa0fd/RJME-64-3-305-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/cbde112faab7/RJME-64-3-305-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/ba06276b1d7f/RJME-64-3-305-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/c17044aaa0fd/RJME-64-3-305-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/cbde112faab7/RJME-64-3-305-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/ba06276b1d7f/RJME-64-3-305-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa5/10720932/c17044aaa0fd/RJME-64-3-305-fig3.jpg

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1
Astrocytes - friends or foes in neurodegenerative disorders.星形胶质细胞——神经退行性疾病的敌是友?
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2
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本文引用的文献

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Subtle vascular and astrocytic changes in the brain of coronavirus disease 2019 (COVID-19) patients.新型冠状病毒病 2019(COVID-19)患者脑部细微的血管和星形胶质细胞变化。
Eur J Neurol. 2022 Dec;29(12):3676-3692. doi: 10.1111/ene.15545. Epub 2022 Oct 1.
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Astrocytes and the Psychiatric Sequelae of COVID-19: What We Learned from the Pandemic.星形胶质细胞与 COVID-19 的精神后遗症:我们从大流行中学到了什么。
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Cellular Distribution of Brain Aquaporins and Their Contribution to Cerebrospinal Fluid Homeostasis and Hydrocephalus.
脑水通道蛋白的细胞分布及其对脑脊液稳态和脑积水的贡献。
Biomolecules. 2022 Mar 31;12(4):530. doi: 10.3390/biom12040530.
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Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection.新型冠状病毒感染的神经后遗症和神经元-胶质细胞平衡破坏。
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Astrocyte-Endotheliocyte Axis in the Regulation of the Blood-Brain Barrier.星形胶质细胞-内皮细胞轴在血脑屏障调节中的作用。
Neurochem Res. 2021 Oct;46(10):2538-2550. doi: 10.1007/s11064-021-03338-6. Epub 2021 May 7.
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Neurotropic Viruses, Astrocytes, and COVID-19.嗜神经病毒、星形胶质细胞与2019冠状病毒病
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7
The role of astrocyte-mediated plasticity in neural circuit development and function.星形胶质细胞介导的可塑性在神经回路发育和功能中的作用。
Neural Dev. 2021 Jan 7;16(1):1. doi: 10.1186/s13064-020-00151-9.
8
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.德国 COVID-19 患者的神经病理学:一项尸检病例系列研究。
Lancet Neurol. 2020 Nov;19(11):919-929. doi: 10.1016/S1474-4422(20)30308-2. Epub 2020 Oct 5.
9
Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.在 COVID-19 中常见的神经胶质细胞和神经元损伤的神经化学证据。
Neurology. 2020 Sep 22;95(12):e1754-e1759. doi: 10.1212/WNL.0000000000010111. Epub 2020 Jun 16.
10
Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes.波形蛋白磷酸化对于未成熟星形细胞的正常细胞分裂是必需的。
Cells. 2019 Sep 1;8(9):1016. doi: 10.3390/cells8091016.