Chen Qi-Yuan, Liu Li, Gu Fang-Zhou
Department of Rheumatology and Nephrology, Jianhu Clinical Medical College of Yangzhou University, Yancheng, China.
Int Wound J. 2023 Oct 22;21(2). doi: 10.1111/iwj.14451.
This study aimed to systematically evaluate the prevalence of surgical site wound infections and postoperative complications after total elbow arthroplasty (TEA) in patients with rheumatoid arthritis (RA) for clinical research and application. Embase, PubMed, Cochrane Library, CNKI, VIP, CBM, and Wanfang databases were electronically searched to collect clinical studies on the application of TEA in the treatment of RA from inception to August 2023. Two independent researchers performed literature screening, data extraction, and quality assessment. A meta-analysis was performed using the R 4.3.1 software. Overall, 26 studies with a total of 2374 patients were included. The results of the meta-analysis revealed that after TEA in patients with RA, the prevalence of surgical site wound infections and postoperative complications was 3.37% (95% confidence interval [CI]: 2.68%-4.13%), and 31.63% (95% CI: 24.97%-38.28%), respectively. The prevalence of surgical site wound infections is low, whereas that of postoperative complications is high; thus, the safety of TEA remains debatable. Owing to limitations on the quality and number of included studies, the findings need to be verified in higher-quality studies.
本研究旨在系统评价类风湿关节炎（RA）患者全肘关节置换术（TEA）后手术部位伤口感染及术后并发症的发生率，以用于临床研究和应用。通过电子检索Embase、PubMed、Cochrane图书馆、中国知网（CNKI）、维普资讯（VIP）、中国生物医学文献数据库（CBM）和万方数据库，收集从开始到2023年8月期间关于TEA治疗RA的临床研究。两名独立研究人员进行文献筛选、数据提取和质量评估。使用R 4.3.1软件进行荟萃分析。共纳入26项研究，总计2374例患者。荟萃分析结果显示，RA患者TEA术后手术部位伤口感染和术后并发症的发生率分别为3.37%（95%置信区间[CI]：2.68%-4.13%）和31.63%（95%CI：24.97%-38.28%）。手术部位伤口感染的发生率较低，而术后并发症的发生率较高；因此，TEA的安全性仍存在争议。由于纳入研究的质量和数量有限，这些结果需要在更高质量的研究中得到验证。
