Demirel Oyku, Gundogdu Selin Oyku, Yuce Sena, Unal Hayriye
Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey.
SUNUM Nanotechnology Research Center, Sabanci University, Istanbul 34956, Turkey.
ACS Omega. 2023 Oct 3;8(41):37908-37917. doi: 10.1021/acsomega.3c03268. eCollection 2023 Oct 17.
Photothermal nanoparticles with light-to-heat conversion properties have gained interest in recent years and have been used in a variety of applications. Herein, indocyanine green (ICG), which is commonly employed as a photothermal agent suffering from low photostability, was loaded into halloysite nanotubes (HNTs) resulting in photothermal HNT-ICG nanohybrids. The photothermal heating patterns of the prepared photothermal nanohybrids as a result of near-infrared (NIR) irradiation were carefully examined. The nanohybrids reached a temperature of 216 °C in 2 min under NIR light, and in contrast to free NIR, the ICG loaded into HNTs remained stable over 10 heating and cooling cycles. Moreover, HNT-ICG nanohybrids incorporated into polyacrylonitrile (PAN) were electrospun into nanofibers for use as photothermal nanofibers, and composite nanofibers, which heat up to 79.3 °C under 2 min of NIR irradiation, were obtained. To demonstrate the potential of the PAN/HNT-ICG nanofibers as light-activated antibacterial nanofibers, their NIR light-activated killing activity on () cells has been explored. The composite nanofibers reduced the number of bacteria on their surface by 7log upon 10 min of NIR irradiation. Encapsulation of ICG in HNTs as a carrier has been demonstrated as an effective way to stabilize ICG and incorporate it into materials and coatings without compromising its functionality.
近年来，具有光热转换特性的光热纳米粒子受到了广泛关注，并已应用于多种领域。在此，将通常用作光热剂但光稳定性较低的吲哚菁绿（ICG）负载到埃洛石纳米管（HNTs）中，得到光热HNT-ICG纳米杂化物。仔细研究了制备的光热纳米杂化物在近红外（NIR）照射下的光热加热模式。在近红外光下，纳米杂化物在2分钟内温度达到216℃，与游离近红外光不同，负载在HNTs中的ICG在10个加热和冷却循环中保持稳定。此外，将HNT-ICG纳米杂化物掺入聚丙烯腈（PAN）中，通过静电纺丝制成纳米纤维用作光热纳米纤维，得到了在近红外照射2分钟内升温至79.3℃的复合纳米纤维。为了证明PAN/HNT-ICG纳米纤维作为光活化抗菌纳米纤维的潜力，研究了它们对（）细胞的近红外光活化杀伤活性。复合纳米纤维在近红外照射10分钟后，其表面细菌数量减少了7个对数级。将ICG封装在HNTs中作为载体已被证明是一种稳定ICG并将其掺入材料和涂层中而不影响其功能的有效方法。
