McArdle C B, Richardson C J, Nicholas D A, Mirfakhraee M, Hayden C K, Amparo E G
Radiology. 1987 Jan;162(1 Pt 1):223-9. doi: 10.1148/radiology.162.1.3786767.
To establish the normal appearance of the neonatal brain, 51 neonates, 29-42 weeks postconception, underwent magnetic resonance (MR) imaging with a 0.6-T magnet in a prospective study. T1-weighted images were used to devise stages for the appearance of gray-white matter differentiation and extent of myelination. The results show that from 29 to 42 weeks postconception, changes in gray-white matter differentiation and myelination follow the stages in an orderly and predictable fashion. Changes in white matter intensity appear related to progressive decrease in brain water content. Myelination progresses cephalad from the brain stem at 29 weeks to reach the centrum semiovale by 42 weeks. Delayed myelination, defined as the absence of myelin in the corona radiata by 37 weeks, was seen in nine infants with complicated perinatal courses. Awareness of these developmental features should help to minimize misinterpretation of normal changes in the neonatal brain and lead to earlier detection of pathologic conditions, both with MR imaging and computed tomography.
为确定新生儿脑的正常表现，在一项前瞻性研究中，对51名孕龄29至42周的新生儿使用0.6-T磁体进行了磁共振（MR）成像检查。利用T1加权图像制定了灰白质分化及髓鞘形成程度的分期。结果显示，从孕龄29周到42周，灰白质分化及髓鞘形成的变化呈有序且可预测的阶段发展。白质信号强度的变化似乎与脑含水量的逐渐减少有关。髓鞘形成从29周时的脑干开始向头侧发展，到42周时到达半卵圆中心。9名围产期情况复杂的婴儿出现了延迟髓鞘形成，即37周时放射冠仍无髓鞘。了解这些发育特征应有助于减少对新生儿脑正常变化的错误解读，并通过MR成像和计算机断层扫描更早地发现病理状况。
