Karvelis K C, Drane W E, Johnson D A, Silverman E D
Radiology. 1987 Jan;162(1 Pt 1):97-9. doi: 10.1148/radiology.162.1.3786789.
Radionuclide esophageal scintigraphy is a sensitive test of esophageal function, but its usefulness is not well documented in Barrett esophagus. This technique was prospectively studied in 27 patients with histologically proved Barrett esophagus and 17 patients with biopsy-confirmed reflux esophagitis. The esophageal transit time and percentage of emptying were calculated. The only quantitative parameter of radionuclide esophageal scintigraphy to show a significant difference between the two conditions was the percentage of emptying, which was abnormal in 48% of patients with Barrett esophagus versus 31% of patients with reflux esophagitis. In the latter group, the mean percentage of emptying approached normal (89.5%), while in the former group it was decreased to 82.1% (P less than .05). Neither emptying parameter correlated with length of Barrett esophagus. These data support the hypothesis of inherent esophageal dysmotility in Barrett esophagus. Half of the patients with this condition have impaired esophageal clearance and may benefit from drug therapy.
放射性核素食管闪烁扫描是一种检测食管功能的敏感方法，但其在巴雷特食管中的应用效果尚无充分记录。本研究前瞻性地纳入了27例经组织学证实的巴雷特食管患者和17例经活检确诊的反流性食管炎患者，对该技术进行了研究。计算食管通过时间和排空百分比。放射性核素食管闪烁扫描中唯一显示两种情况有显著差异的定量参数是排空百分比，巴雷特食管患者中有48%异常，而反流性食管炎患者中有31%异常。在后一组中，平均排空百分比接近正常（89.5%），而在前一组中则降至82.1%（P<0.05）。两个排空参数均与巴雷特食管的长度无关。这些数据支持巴雷特食管存在固有食管运动障碍的假说。患有这种疾病的患者中有一半存在食管清除功能受损，可能从药物治疗中获益。
