Coates Matthew D, Clarke Kofi, Williams Emmanuelle, Jeganathan Nimalan, Yadav Sanjay, Giampetro David, Gordin Vitaly, Smith Sadie, Vrana Kent, Bobb Anne, Gazzio Thu Thi, Tressler Heather, Dalessio Shannon
Department of Medicine, Division of Gastroenterology & Hepatology, Penn State College of Medicine, Hershey, PA, USA.
Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Crohns Colitis 360. 2023 Sep 26;5(4):otad055. doi: 10.1093/crocol/otad055. eCollection 2023 Oct.
Abdominal pain is one of the most common and impactful symptoms associated with inflammatory bowel disease (IBD), including both Crohn's disease and ulcerative colitis. A great deal of research has been undertaken over the past several years to improve our understanding and to optimize management of this issue. Unfortunately, there is still significant confusion about the underlying pathophysiology of abdominal pain in these conditions and the evidence underlying treatment options in this context. There is also a relative paucity of comprehensive reviews on this topic, including those that simultaneously evaluate pharmacological and nonpharmacological therapeutic options. In this review, our multidisciplinary team examines evidence for various currently available medical, surgical, and other analgesic options to manage abdominal pain in IBD.
腹痛是与炎症性肠病(IBD)相关的最常见且影响较大的症状之一,炎症性肠病包括克罗恩病和溃疡性结肠炎。在过去几年里,人们进行了大量研究,以增进我们对这一问题的理解并优化其管理。不幸的是,对于这些情况下腹痛的潜在病理生理学以及在此背景下治疗选择的依据,仍然存在很大的困惑。关于这一主题的全面综述也相对较少,包括那些同时评估药物和非药物治疗选择的综述。在本综述中,我们的多学科团队研究了目前各种可用的医学、外科和其他镇痛方法用于管理炎症性肠病腹痛的证据。