Pillay Shakti, Horn Alan R, Tooke Lloyd
Neonatal Unit, Groote Schuur Hospital, Cape Town, South Africa.
Division of Neonatology, Department of Paediatrics, University of Cape Town, Cape Town, South Africa.
Front Pediatr. 2023 Oct 6;11:1215387. doi: 10.3389/fped.2023.1215387. eCollection 2023.
Syphilis during pregnancy remains an important global health concern causing miscarriage, stillbirth, preterm birth and neonatal death. As part of the fetal infection, placental changes occur which may include a heavier placenta than expected.
A cohort of 50 neonates with symptomatic congenital syphilis has previously been described. This cohort was admitted to Groote Schuur neonatal unit in Cape Town South Africa from 2011 to 2013. For this study, the placental weights of the neonates were analyzed and compared to population based placental centiles.
There was data for 37 placentae. Heavy placentae (>90th centile) occurred in 76% of placentae in the study. All 6 infants with birth weights ≥2,500 g had heavy placentae. There was no correlation between placental centile and death.
Heavy placenta are an important and frequent finding with symptomatic congenital syphilis, especially in the larger neonates.
孕期梅毒仍是一个重要的全球健康问题，可导致流产、死产、早产和新生儿死亡。作为胎儿感染的一部分，胎盘会发生变化，其中可能包括胎盘比预期的更重。
此前已描述了一组50例有症状先天性梅毒的新生儿。该队列于2011年至2013年入住南非开普敦的格罗特舒尔新生儿病房。在本研究中，对这些新生儿的胎盘重量进行了分析，并与基于人群的胎盘百分位数进行了比较。
有37个胎盘的数据。在研究中，76%的胎盘较重（>第90百分位数）。所有6例出生体重≥2500g的婴儿胎盘都较重。胎盘百分位数与死亡之间无相关性。
胎盘较重是有症状先天性梅毒的一个重要且常见的表现，尤其是在较大的新生儿中。
