Louis-Jean Scarlet, Agrawal Nirav, Chaudhry Shire, Mazer Adrien
Department of Internal Medicine, Luminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
J Community Hosp Intern Med Perspect. 2023 Sep 2;13(5):94-96. doi: 10.55729/2000-9666.1239. eCollection 2023.
Stiff person syndrome (SPS) and biliary dyskinesia are two rare but potentially debilitating conditions that can significantly impact quality of life. SPS is a rare neurological disorder characterized by muscle stiffness, rigidity, and muscle spasms that primarily affect the trunk and limbs and is associated with extra-axial manifestations involving the gastrointestinal tract. Biliary dyskinesia is a gastrointestinal disorder characterized by abnormal gallbladder emptying, leading to symptoms of intense abdominal pain, nausea, and vomiting. Despite their distinct clinical presentations, studies have suggested a possible connection between the two disorders. This link may be due to involvement of similar neurotransmitters and autoantibodies in both conditions. In this report, we present a case of biliary dyskinesia in a 58-year-old male with prior history of chronic gastrointestinal symptoms, autoimmune disease, and SPS. Given the rarity of these conditions, there is a need for increased awareness and improved diagnostic modalities to facilitate early detection and management.
僵人综合征（SPS）和胆囊运动障碍是两种罕见但可能使人衰弱的病症，会对生活质量产生重大影响。僵人综合征是一种罕见的神经系统疾病，其特征为肌肉僵硬、强直及肌肉痉挛，主要影响躯干和四肢，并伴有涉及胃肠道的轴外表现。胆囊运动障碍是一种胃肠道疾病，其特征为胆囊排空异常，导致剧烈腹痛、恶心和呕吐等症状。尽管它们有不同的临床表现，但研究表明这两种疾病之间可能存在联系。这种联系可能是由于两种病症中存在相似的神经递质和自身抗体。在本报告中，我们介绍了一名58岁男性胆囊运动障碍的病例，该患者既往有慢性胃肠道症状、自身免疫性疾病和僵人综合征病史。鉴于这些病症的罕见性，需要提高认识并改进诊断方法，以促进早期发现和管理。
