Asaduzzaman Md, Roy Soumitra, Das Pew Nibedita, Roy Anindya Deb, Kibria Shahrin, Roy Ranjon Kumer, Alam M M Jahangir, Chakraborty Shishir Ranjan
Department of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet 3100, Bangladesh.
Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet 3100, Bangladesh.
Toxicol Rep. 2023 Oct 14;11:350-354. doi: 10.1016/j.toxrep.2023.10.008. eCollection 2023 Dec.
Paraquat poisoning is one of the leading causes of fatal poisoning in many parts of the world, especially in agricultural countries. Its high toxicity even in small amounts causes rapid damage to multiple organs, especially the kidneys, lungs, and liver, mainly through free radical-mediated injury. As no specific antidote is yet available, early diagnosis and the importance of supportive therapy are critical parts of management. Some evidence suggests a survival benefit from using immunosuppressive drugs.
This case presentation concerns a 15-year-old boy from a village with a history of herbicide poisoning, later confirmed to be paraquat. Despite supportive therapy her condition continued to deteriorate with features of kidney and lung damage. The patient was then treated with methylprednisolone 500 mg daily for 5 days, along with other supportive care, and has made a remarkable recovery.
High efficacy as an herbicide, availability and low cost make paraquat an easy-to-encounter poison for suicidal or accidental use. Its high fatality calls for urgent and effective strategies to save lives. Methylprednisolone may play a role in its treatment.
百草枯中毒是世界许多地区，尤其是农业国家中毒致死的主要原因之一。即使少量摄入，其高毒性也会通过自由基介导的损伤，对多个器官，尤其是肾脏、肺和肝脏造成快速损害。由于目前尚无特效解毒剂，早期诊断和支持治疗的重要性是治疗管理的关键部分。一些证据表明使用免疫抑制药物可带来生存益处。
本病例介绍的是一名来自农村的15岁男孩，有除草剂中毒史，后来确诊为百草枯中毒。尽管进行了支持治疗，但其病情仍继续恶化，并出现肾脏和肺部损伤的症状。随后，该患者接受了为期5天的每日500毫克甲泼尼龙治疗，同时接受其他支持性护理，并已显著康复。
百草枯作为除草剂效果高、易得且成本低，使其成为自杀或意外使用时容易接触到的毒物。其高致死率需要采取紧急有效的策略来挽救生命。甲泼尼龙可能在其治疗中发挥作用。
