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意外摄入百草枯导致唾液分泌过多:一例报告。

Accidental paraquat induced hypersalivation: a case report.

机构信息

Department of Pharmacy Practice, JSS College of Pharmacy, Ooty, India.

JSS Academy of Higher Education and Research, Mysuru, India.

出版信息

Daru. 2019 Dec;27(2):885-888. doi: 10.1007/s40199-019-00298-9. Epub 2019 Sep 5.

Abstract

Paraquat is one of the most commonly used lethal herbicide. Even the small amount of paraquat is hazardous to human beings. Poisoning by paraquat is most commonly happening in agricultural based economical country. This poison is a threat to public health and its high mortality rate is responsible for a significant number of death. We hereby report a case of 38-year-old male with a history of accidental paraquat ingestion. He works as a gardener which contributes to the ease in availability of the poison. He had the post accidental paraquat consumption complaints of lip sores, swallowing difficulty and hypersalivation in more amount. The patient was admitted in the Casualty and underwent the supportive treatment. Laboratory investigations were found to be normal except WBC count which was elevated. Early diagnosis and proper management can reduce the mortality rate and even small amount of paraquat can lead to some major fatal outcomes. At present there is no specific antidote available so there is a need to focus more on the prevention and management of paraquat poisoning.

摘要

百草枯是最常用的除草剂之一。即使是少量的百草枯对人类也是危险的。百草枯中毒最常见于以农业为基础的经济国家。这种毒药对公共健康构成威胁,其高死亡率导致了大量死亡。我们在此报告一例 38 岁男性,有意外摄入百草枯的病史。他是一名园丁,这使得这种毒药更容易获得。他在意外摄入百草枯后出现唇部溃疡、吞咽困难和唾液分泌过多的症状。患者被收入急诊科,并接受了支持性治疗。实验室检查除白细胞计数升高外均正常。早期诊断和适当的治疗可以降低死亡率,即使是少量的百草枯也会导致一些严重的致命后果。目前尚无特效解毒剂,因此需要更加注重百草枯中毒的预防和管理。

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本文引用的文献

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Role of antioxidants in paraquat toxicity.抗氧化剂在百草枯毒性中的作用。
Toxicology. 2002 Oct 30;180(1):65-77. doi: 10.1016/s0300-483x(02)00382-7.
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