Holmes Ashley A, Matarazzo Michele, Mondesire-Crump Ijah, Katz Emily, Mahajan Rahul, Arroyo-Gallego Teresa
nQ Medical Cambridge Massachusetts USA.
HM CINAC (Centro Integral de Neurociencias Abarca Campal), Fundación Hospitales de Madrid Hospital Universitario HM Puerta del Sur, HM Hospitales Madrid Spain.
Mov Disord Clin Pract. 2023 Aug 25;10(10):1530-1535. doi: 10.1002/mdc3.13864. eCollection 2023 Oct.
The nQiMechPD algorithm transforms natural typing data into a numerical index that characterizes motor impairment in people with Parkinson's Disease (PwPD).
Use nQiMechPD to compare asymmetrical progression of PD-related impairment in dominant (D-PD) versus non-dominant side onset (ND-PD) de-novo patients.
Keystroke data were collected from 53 right-handed participants (15 D-PD, 13 ND-PD, 25 controls). We apply linear mixed effects modeling to evaluate participants' right, left, and both hands nQiMechPD relative change by group.
The 6-month nQiMechPD trajectories of right (** = 0.002) and both (* = 0.043) hands showed a significant difference in nQiMechPD trends between D-PD and ND-PD participants. Left side trends were not significantly different between these two groups ( = 0.328).
Significant differences between D-PD and ND-PD groups were observed, likely driven by contrasting dominant hand trends. Our findings suggest disease onset side may influence motor impairment progression, medication response, and functional outcomes in PwPD.
nQiMechPD算法将自然打字数据转化为一个数值指标，用于表征帕金森病患者（PwPD）的运动障碍。
使用nQiMechPD比较首发的优势侧发病（D-PD）与非优势侧发病（ND-PD）帕金森病患者中与帕金森病相关损伤的不对称进展情况。
从53名右利手参与者（15名D-PD患者、13名ND-PD患者、25名对照）收集击键数据。我们应用线性混合效应模型按组评估参与者右手、左手及双手的nQiMechPD相对变化。
右手（** = 0.002）和双手（* = 0.043）的6个月nQiMechPD轨迹显示，D-PD和ND-PD参与者之间的nQiMechPD趋势存在显著差异。两组之间左侧趋势无显著差异（ = 0.328）。
观察到D-PD组和ND-PD组之间存在显著差异，可能是由优势手趋势的对比所驱动。我们的研究结果表明疾病发病侧可能会影响帕金森病患者的运动障碍进展、药物反应和功能结局。
