Cancer Biomarkers Research Group, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland.
Department of Biomedicine, University of Bergen, Bergen, Norway.
Front Immunol. 2023 Oct 5;14:1236301. doi: 10.3389/fimmu.2023.1236301. eCollection 2023.
Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and longevity. At the same time, it serves as a significant contributor to acidification of the tumor microenvironment, which, in turn, imposes substantial constraints on infiltrating immune cells. Here, we delve into the influence of tumor-derived lactic acid on innate lymphoid cells (ILCs) and discuss potential therapeutic approaches. Given the abundance of ILCs in barrier tissues such as the skin, we provide insights aimed at translating this knowledge into therapies that may specifically target skin cancer.
有氧糖酵解，又称为瓦博格效应，长期以来被视为肿瘤代谢的一个显著特征。癌细胞将葡萄糖利用重新导向为乳酸的大量生成，使它们能够快速增殖、持续生长和长寿。同时，这也导致肿瘤微环境的酸化，从而对浸润的免疫细胞施加了巨大的限制。在这里，我们深入探讨了肿瘤衍生的乳酸对先天淋巴细胞（ILCs）的影响，并讨论了潜在的治疗方法。鉴于 ILCs 在皮肤等屏障组织中大量存在，我们提供了旨在将这些知识转化为可能专门针对皮肤癌的治疗方法的见解。
