Yu Nianzhou, Huang Kai, Li Yixin, Jiang Zixi, Liu Siliang, Liu Yuancheng, Liu Xiaowan, Chen Zeyu, He Renliang, Wei Tianhong
Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Oncol. 2023 Oct 5;13:1185389. doi: 10.3389/fonc.2023.1185389. eCollection 2023.
Despite the increasing use of preoperative ultrasound evaluation for melanoma, there is limited research on the use of this technique for Acral Melanoma (AM).
This retrospective study analyzed the electronic medical records of patients who underwent preoperative evaluation for cutaneous melanoma maximum thickness using an 18 MHz probe and histopathological examination between December 2017 and March 2021 at the Department of Dermatology in Xiangya Hospital, Central South University.
A total of 105 patients were included in the study. The mean tumor thickness was 3.9 mm (s.d., 2.3), with 63% of the specimens showing ulceration and 44 patients showing lymph node metastasis. The results showed a good correlation between the high-frequency ultrasonography (HFUS) and histopathological thickness measurements, with a Spearman's correlation coefficient of 0.83 [(95% CI 0.73-0.90) (P < 0.001)]. The positive predictive value (PPV) of sonography in identifying tumor thickness was also found to be high.
Our study suggests that high-frequency 18 MHz ultrasonography is an effective tool for the preoperative evaluation of AM thickness. The HFUS measurements correlated well with the histopathological thickness measurements, making it a valuable and reliable method for clinicians to assess the thickness of melanoma lesions preoperatively.
尽管术前超声评估在黑色素瘤中的应用日益增多，但关于该技术在肢端黑色素瘤（AM）中的应用研究有限。
这项回顾性研究分析了2017年12月至2021年3月期间在中南大学湘雅医院皮肤科接受术前评估的皮肤黑色素瘤患者的电子病历，评估使用18MHz探头测量最大厚度，并进行组织病理学检查。
本研究共纳入105例患者。肿瘤平均厚度为3.9mm（标准差2.3），63%的标本显示溃疡，44例患者有淋巴结转移。结果显示高频超声（HFUS）与组织病理学厚度测量之间具有良好的相关性，Spearman相关系数为0.83[（95%CI 0.73 - 0.90）（P < 0.001）]。超声检查在识别肿瘤厚度方面的阳性预测值（PPV）也很高。
我们的研究表明，18MHz高频超声是术前评估AM厚度的有效工具。HFUS测量结果与组织病理学厚度测量结果相关性良好，使其成为临床医生术前评估黑色素瘤病变厚度的一种有价值且可靠的方法。
