Watanabe H, Menzies J A
Res Commun Chem Pathol Pharmacol. 1986 Nov;54(2):271-4.
The effect of the antifungal agent, ketoconazole, on rat ovarian concentration of progestins and androgens was investigated. A single oral dose of 20 mg/kg on the morning of proestrus resulted 3h later in a significant decrease. Control values at this time for progesterone, 17 alpha-hydroxyprogesterone, androstenedione and testosterone were 1173, 53, 40 and 2.5 ng/100 mg tissue respectively. In ketoconazole treated rats, the corresponding concentrations were 837, 34, 23 and 0.7 ng/100 mg tissue respectively. At a dose of 5 mg/kg ketoconazole, the concentrations of these steroids tended to be lower but the differences from control were not statistically significant.
研究了抗真菌剂酮康唑对大鼠卵巢中孕激素和雄激素浓度的影响。在动情前期早晨单次口服20mg/kg剂量，3小时后导致显著下降。此时孕酮、17α-羟孕酮、雄烯二酮和睾酮的对照值分别为1173、53、40和2.5ng/100mg组织。在酮康唑处理的大鼠中，相应浓度分别为837、34、23和0.7ng/100mg组织。给予5mg/kg酮康唑剂量时，这些类固醇的浓度趋于降低，但与对照的差异无统计学意义。
