Wan Wei, Qiu Yi, Huang Xinyi, Ren Yingxiang, Peng Andi, Yang Chunping
Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Front Microbiol. 2023 Oct 6;14:1190765. doi: 10.3389/fmicb.2023.1190765. eCollection 2023.
Growing evidence has well documented the close association between the gut microbiome and allergic respiratory disease, which has been notably represented by allergic asthma. However, it is unclear whether this association is a causal link. Therefore, we investigated the potential causal associations between the gut microbiome and allergic asthma or other allergic diseases.
In this study, we performed two-sample Mendelian randomization (MR) analyses by using the publicly available genome-wide association study (GWAS) summary data. Single-nucleotide polymorphisms (SNPs) that significantly correlated were selected as instrumental variables. The inverse variance weighted (IVW) method was used to examine the potential causal gut microbial genera for allergic asthma and other allergic diseases. The robustness of the primary findings of the MR analyses was ensured by using different sensitivity analyses.
Combining the findings from multiple analyses, the host genetic-driven increases in at the genus level were positively correlated with the risk of allergic asthma. In addition, phylum and class were also found to have negative associations with the risk of allergic asthma; genus was identified as having potential causal effects with allergic asthma. No clear evidence of pleiotropy and heterogeneity was observed in genus . was also found to have an association with allergic rhinitis, but not with other allergic diseases.
Our findings indicate that there are new gut microbial genera that were causally associated with the risk of allergic asthma and other allergic diseases, and offer novel insights into the pathogenesis of allergic respiratory diseases.
越来越多的证据充分证明了肠道微生物群与过敏性呼吸道疾病之间的密切关联，其中过敏性哮喘尤为典型。然而，尚不清楚这种关联是否为因果关系。因此，我们研究了肠道微生物群与过敏性哮喘或其他过敏性疾病之间的潜在因果关联。
在本研究中，我们通过使用公开可用的全基因组关联研究（GWAS）汇总数据进行了两样本孟德尔随机化（MR）分析。选择显著相关的单核苷酸多态性（SNP）作为工具变量。采用逆方差加权（IVW）方法研究过敏性哮喘和其他过敏性疾病潜在的因果肠道微生物属。通过使用不同的敏感性分析来确保MR分析主要结果的稳健性。
综合多项分析结果，宿主基因驱动的属水平的增加与过敏性哮喘风险呈正相关。此外，还发现门和纲与过敏性哮喘风险呈负相关；属被确定与过敏性哮喘具有潜在因果效应。在属中未观察到明显的多效性和异质性证据。还发现与过敏性鼻炎有关，但与其他过敏性疾病无关。
我们的研究结果表明，存在与过敏性哮喘和其他过敏性疾病风险有因果关联的新的肠道微生物属，并为过敏性呼吸道疾病的发病机制提供了新的见解。
