Fuke Keito, Miura Tomoya
Division of Applied Chemistry, Okayama University, Tsushimanaka, Okayama 700-8530, Japan.
Org Biomol Chem. 2023 Nov 8;21(43):8642-8645. doi: 10.1039/d3ob01533e.
A regioselective 1,2-hydro(cyanomethylation) of unactivated aliphatic alkenes is reported. A cyanomethyl radical is generated from haloacetonitriles. This radical adds onto alkenes to form alkyl radicals, which undergo hydrogen atom transfer from thiol to produce one-carbon-extended nitriles. Furthermore, the alkyl radicals are applied to cascade cyclization.
