Department of Geriatrics, Hospital Virgen del Valle, Hospital Universitario de Toledo, Toledo, Spain.
CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Geroscience. 2024 Feb;46(1):609-620. doi: 10.1007/s11357-023-00966-4. Epub 2023 Oct 23.
In the ageing process, the vascular system undergoes morphological and functional changes that may condition brain functioning; for this reason, the aims of this study were to assess the effect of vascular function indirectly measured by ankle-brachial index (ABI) on both cognitive performance at baseline and change in cognitive performance at end of follow-up. We developed a prospective, population-based, cohort study with 1147 participants aged > 65 years obtained from the Toledo Study for Healthy Ageing who had cognitive assessment and measured ABI in the first wave (2006-2009) were selected for the cross-sectional analysis. Those participants who also performed the cognitive assessment in the second wave (2011-2013) were selected for the prospective analysis. Cognitive impairment diagnosis and symptoms and/or history of cardio/neurovascular disease were used as exclusion criteria. Multivariate segmented regression model was used to assess the associations between ABI and cognitive performance in both the cross-sectional and prospective analyses. As ABI score decreased from 1.4, the cross-sectional analysis showed a higher decrease in cognitive performance and the prospective analysis showed a higher degree of worsening in cognitive performance. Our findings suggest that the ABI, a widespread measure of vascular health in primary care, may be a useful tool for predicting cognitive performance and its evolution.
在衰老过程中，血管系统会发生形态和功能上的变化，从而影响大脑功能；因此，本研究的目的是评估间接通过踝臂指数（ABI）测量的血管功能对认知表现基线和随访结束时认知表现变化的影响。我们开展了一项前瞻性、基于人群的队列研究，共纳入了 1147 名年龄大于 65 岁的参与者，这些参与者来自托莱多健康老龄化研究，他们在第一波（2006-2009 年）进行了认知评估和踝臂指数测量，被选为横断面分析的对象。那些还在第二波（2011-2013 年）进行了认知评估的参与者被选为前瞻性分析的对象。认知障碍诊断以及心血管/神经血管疾病的症状和/或病史被用作排除标准。多变量分段回归模型用于评估横断面和前瞻性分析中 ABI 和认知表现之间的关联。随着 ABI 评分从 1.4 下降，横断面分析显示认知表现下降幅度更大，前瞻性分析显示认知表现恶化程度更高。我们的研究结果表明，ABI 作为初级保健中广泛用于评估血管健康的指标，可能是预测认知表现及其演变的有用工具。
