β受体阻滞剂对运动双倍乘积（收缩压×心率）的影响。
Effect of beta-blockers on exercise double product (systolic blood pressure x heart rate).
作者信息
Vukovich R A, Foley J E, Brown B, Willard D A, Buckley M, O'Kelly D, Fitzgerald D, Tormey W, Darragh A
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):167S-172S. doi: 10.1111/j.1365-2125.1979.tb04687.x.
Abstract
1 The effect of single oral doses of six beta-receptor antagonists on exercise-induced changes in double product (systolic blood pressure x heart rate) were studied in 25 human volunteers. 2 Three doses of propranolol, nadolol, oxprenolol, pindolol, timolol and atenolol were selected for study on the basis of in vivo beta-blocking potency. 3 Although all beta-blockers studied reduced the double product response to exercise, the pharmacodynamics of this effect differed markedly. 4 Pharmacodynamic half-lives, estimated for the drug tested, were 39 h for nadolol, atenolol 21 h, timolol 15 h, oxprenolol 13 h, propranolol 11 and pindolol 8 h. 5 These results suggest that the clinical choice of a beta-blocker with the least problems of compliance can be made on the basis of pharmacodynamics as well as pharmacological profile.
摘要
- 研究了25名人类志愿者单次口服六种β受体拮抗剂对运动诱导的双乘积（收缩压×心率）变化的影响。2. 根据体内β受体阻断效能，选择了三种剂量的普萘洛尔、纳多洛尔、氧烯洛尔、吲哚洛尔、噻吗洛尔和阿替洛尔进行研究。3. 虽然所研究的所有β受体阻滞剂都降低了运动时的双乘积反应，但这种效应的药效学有显著差异。4. 所测药物的药效学半衰期，纳多洛尔为39小时，阿替洛尔为21小时，噻吗洛尔为15小时，氧烯洛尔为13小时，普萘洛尔为11小时，吲哚洛尔为8小时。5. 这些结果表明，可根据药效学以及药理学特征来选择临床应用中依从性问题最少的β受体阻滞剂。
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