Danieli G, Marchegiani G, Gabrielli A
Ric Clin Lab. 1986 Apr-Jun;16(2):393-401. doi: 10.1007/BF02909368.
Our data confirm those already reported in the literature. There is no univocal therapy for essential cryoglobulinemia. Several therapeutic strategies may be employed according to severity of the clinical picture. Skin and articular involvement may benefit from the administration of non-steroidal antiinflammatory drugs. The presence of visceral involvement requires steroids and/or immunosuppressive drugs. Plasma-exchange should be used in patients with severe progressive disease. However, data showing that anyone of the proposed treatment could irreversibly stop the clinical course of the disease are lacking. Immunological parameters except serum viscosity cannot help in the decision to initiate a plasma-exchange program and in monitoring its efficacy.
我们的数据证实了文献中已报道的那些内容。对于原发性冷球蛋白血症不存在单一的治疗方法。根据临床表现的严重程度可采用几种治疗策略。皮肤和关节受累可能受益于非甾体抗炎药的使用。内脏受累则需要使用类固醇和/或免疫抑制药物。对于严重进展性疾病的患者应采用血浆置换。然而，缺乏数据表明所提出的任何一种治疗方法都能不可逆地阻止该疾病的临床进程。除血清粘度外，免疫参数无助于决定启动血浆置换方案以及监测其疗效。
