Bombardieri S, Ferri C, Migliorini P, Puccetti A, Vitali C, Moriconi L, Fosella P V
Int J Artif Organs. 1985 Jul;8 Suppl 2:7-10.
A number of immunological parameters were measured in 9 patients with essential mixed cryoglobulinemia and 12 patients with systemic lupus erythematosus undergoing plasma exchange alone or without cytotoxic drugs. Only cryocrit significantly decreased in the majority of patients with essential mixed cryoglobulinemia. In contrast, immune complex levels, measured in two different ways, did not change on the whole, although variable and unpredictable changes were often present in individual patients. Thus, these data do not support the view that the mechanism(s) of action of plasma exchange in these diseases is only due to the quantitative removal of circulating immune complexes, and qualitative changes in the immune complex moiety may also occur.
对9例原发性混合性冷球蛋白血症患者和12例系统性红斑狼疮患者进行了一些免疫学参数的测量，这些患者单独接受血浆置换或未使用细胞毒性药物。在大多数原发性混合性冷球蛋白血症患者中，只有冷沉淀比容显著降低。相比之下，尽管个别患者经常出现变化无常且不可预测的变化，但用两种不同方法测量的免疫复合物水平总体上没有变化。因此，这些数据不支持血浆置换在这些疾病中的作用机制仅归因于循环免疫复合物的定量清除这一观点，免疫复合物部分也可能发生质的变化。
