Nadal C
Toxicol Pathol. 1986;14(3):349-52. doi: 10.1177/019262338601400310.
Studies of hepatocyte proliferation during physiologic growth of the rat and after experimental stimulations such as partial hepatectomy and injection of irritants show that an inhibitory mechanism is associated with decreasing proliferation and causes hepatocytes to be less sensitive to mitotic stimuli. An inhibitory glycopeptide linked to a high molecular weight protein, alpha 2-macroglobulin in man, has been characterized. This glycopeptide blocks the cell cycle of hepatocytes at the G1-S transition in vivo.
对大鼠生理性生长期间以及在诸如部分肝切除和注射刺激物等实验性刺激后肝细胞增殖的研究表明，一种抑制机制与增殖减少相关，并导致肝细胞对有丝分裂刺激的敏感性降低。一种与高分子量蛋白质（人类中的α2-巨球蛋白）相连的抑制性糖肽已得到鉴定。这种糖肽在体内可阻断肝细胞在G1-S期转换时的细胞周期。
