Nadal C
Virchows Arch B Cell Pathol. 1975 Sep 11;18(4):273-80. doi: 10.1007/BF02889253.
A serum factor that inhibits the passage of hepatocytes from the G1 to the S phase and another that induces the production of binucleate hepatocytes were studied at different growth stages in the rat and under conditions inducing hepatocyte multiplication: partial hepatectomy and injection of irritants. A close relationship was found between the presence of these serum factors and the patterns of hepatocyte multiplication. When many S phase hepatocytes and few binucleate cells are produced in the liver, as in the first three weeks of life or after partial hepatectomy in adults, the mitotic inhibition and binucleate cell production activities are not found in the sera. Conversely, when the number of S phase hepatocytes decreases progressively and many binucleate cells are produced, as in weanling and adult rats or in baby rats during the late period after an irritating injection, these activities are present in the sera. These facts support the hypothesis that these factors play a role in the physiological regulatory mechanism of liver growth.
在大鼠不同生长阶段以及诱导肝细胞增殖的条件下，即部分肝切除和注射刺激物后，对一种抑制肝细胞从G1期进入S期的血清因子以及另一种诱导双核肝细胞产生的血清因子进行了研究。发现这些血清因子的存在与肝细胞增殖模式之间存在密切关系。当肝脏中产生许多S期肝细胞且双核细胞很少时，如在生命的前三周或成年大鼠部分肝切除后，血清中未发现有丝分裂抑制和双核细胞产生活性。相反，当S期肝细胞数量逐渐减少且产生许多双核细胞时，如在断奶大鼠和成年大鼠中，或在刺激性注射后的幼鼠后期，血清中存在这些活性。这些事实支持了这样一种假说，即这些因子在肝脏生长的生理调节机制中起作用。
