Dadzie K Y, Remme J, Rolland A, Thylefors B
Trop Med Parasitol. 1986 Sep;37(3):263-70.
The evolution of ocular onchocerciasis was studied in a cohort of 1170 persons over 5 years of age who were examined before the start of and after 7-8 years of effective vector control in 12 originally hyperendemic villages in the central part of the OCP area. The proportion of the cohort which at the outset of vector control was free from ocular onchocerciasis or had an early or recent infection in the form of punctate keratitis only, remained largely free of or lost their signs of ocular infection respectively and only a very insignificant proportion acquired microfilariae in the eyes or developed a severe onchocercal eye lesion at the initial stage. The proportion of the cohort with a heavy ocular microfilarial load had a reduced risk of developing severe eye lesions and no risk of going blind. The proportion of the cohort with already existing severe eye lesions at the advanced stage remained largely unchanged and some lesions at the initial stage disappeared. Blindness occurred only in those who had severe eye lesions at the outset and was comparatively less than in areas of on-going transmission.
在盘尾丝虫病控制计划（OCP）区域中部12个原本高度流行的村庄，对1170名5岁以上的人群进行了队列研究，以观察盘尾丝虫性眼病的演变情况。这些人在有效的病媒控制开始前以及开始后7 - 8年接受了检查。在病媒控制开始时，该队列中没有盘尾丝虫性眼病或仅患有点状角膜炎形式的早期或近期感染的比例，分别基本保持无眼部感染体征或失去了眼部感染体征，只有极小比例的人在初期眼睛中获得了微丝蚴或发展为严重的盘尾丝虫性眼病变。眼部微丝蚴负荷重的队列比例发生严重眼病变的风险降低，且没有失明风险。该队列中在晚期已存在严重眼病变的比例基本保持不变，一些初期病变消失。失明仅发生在那些一开始就患有严重眼病变的人身上，且相较于仍在传播的地区，失明的人数相对较少。
