Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Genetics, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Pathol Res Pract. 2023 Nov;251:154900. doi: 10.1016/j.prp.2023.154900. Epub 2023 Oct 20.
Circular RNAs (circRNAs) are a class of RNA molecules that are characterized by their covalently closed structure, which is formed through a process of back splicing of the precursor mRNA. Abnormal expression of circRNAs has been shown to indirectly affect their interaction with microRNAs (miRNAs), thereby modulating gene transcription. One such circRNA, circ_0000285, is known to be dysregulated in various cancers and human diseases. This circRNA is derived from the HIPK3 gene on chromosome 11 and acts as a competing endogenous RNA for several miRNAs, including miR-654-3p, miR-197-3p, miR-1278, miR-582-3p, and miR-599. Notably, circ_0000285 has been linked to poor overall survival and several clinicopathological features in multiple human cancers. In this review, we present a comprehensive summary of the oncogenic effect of circ_0000285 in various cancers, drawing on experiment performed on cell lines, animals, and human tissues. Furthermore, we predicted potential miRNAs and RNA-binding proteins that may interact with circ_0000285, thereby providing new insights for further studies.
环状 RNA（circRNAs）是一类 RNA 分子，其特征为共价闭环结构，通过前体 mRNA 的反向剪接过程形成。circRNAs 的异常表达已被证明可间接影响其与 microRNAs（miRNAs）的相互作用，从而调节基因转录。circ_0000285 是一种已知在多种癌症和人类疾病中失调的环状 RNA。该环状 RNA 来源于 11 号染色体上的 HIPK3 基因，作为几种 miRNA 的竞争性内源 RNA，包括 miR-654-3p、miR-197-3p、miR-1278、miR-582-3p 和 miR-599。值得注意的是，circ_0000285 与多种人类癌症中的总生存期不良和几种临床病理特征有关。在这篇综述中，我们综合总结了 circ_0000285 在各种癌症中的致癌作用，参考了在细胞系、动物和人类组织中进行的实验。此外，我们预测了可能与 circ_0000285 相互作用的潜在 miRNA 和 RNA 结合蛋白，为进一步研究提供了新的见解。
